Yoshio Shirai Selected Research

monoclonal antibody D2-40

1/2010	Mode of hepatic spread from gallbladder carcinoma: an immunohistochemical analysis of 42 hepatectomized specimens.
12/2007	Intrahepatic lymphatic invasion independently predicts poor survival and recurrences after hepatectomy in patients with colorectal carcinoma liver metastases.
9/2007	Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders.

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Yoshio Shirai Research Topics

Disease

31	Neoplasms (Cancer) 01/2018 - 02/2002
18	Neoplasm Metastasis (Metastasis) 10/2015 - 02/2002
16	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 02/2002
12	Hepatocellular Carcinoma (Hepatoma) 02/2012 - 01/2005
11	Carcinoma (Carcinomatosis) 10/2015 - 07/2002
10	Cholangiocarcinoma 10/2021 - 11/2005
5	Gallbladder Neoplasms (Gallbladder Cancer) 09/2012 - 01/2007
3	Neoplasm Micrometastasis 01/2012 - 03/2002
3	Cholelithiasis 09/2004 - 01/2004
2	Cysts 02/2013 - 01/2002
2	Klatskin Tumor 11/2012 - 11/2009
2	Colonic Neoplasms (Colon Cancer) 10/2009 - 12/2005
2	Residual Neoplasm 04/2009 - 11/2005
2	Hernia (Hernias) 03/2006 - 03/2006
2	Gallstones (Gallstone) 09/2004 - 01/2004
1	Hand-Foot Syndrome 10/2015
1	Stomatitis 10/2015
1	Carcinoma in Situ 03/2013
1	Biliary Tract Neoplasms (Biliary Tract Cancer) 02/2013
1	Fibrosis (Cirrhosis) 12/2012
1	Inflammation (Inflammations) 12/2012
1	Sclerosing Cholangitis 12/2012
1	Metaplasia 11/2011
1	Non-alcoholic Fatty Liver Disease 08/2011
1	Hepatitis 08/2011
1	Primitive Neuroectodermal Tumors (PNET) 03/2011
1	Abdominal Pain (Pain, Abdominal) 03/2011
1	Necrosis 04/2010
1	Interstitial Lung Diseases (Interstitial Lung Disease) 10/2009
1	Hepatoblastoma 08/2009
1	Paraneoplastic Syndromes (Paraneoplastic Syndrome) 04/2009
1	Polycythemia (Erythrocytosis) 04/2009
1	Hyperlipidemias (Hyperlipidemia) 04/2009
1	Lymphatic Metastasis 01/2009
1	Microsatellite Instability 01/2008
1	Rectal Neoplasms (Rectal Cancer) 02/2007
1	Reperfusion Injury 07/2006
1	Lung Neoplasms (Lung Cancer) 06/2006
1	Liver Neoplasms (Liver Cancer) 03/2006

Drug/Important Bio-Agent (IBA)

9	Fluorouracil (Carac)FDA LinkGeneric 03/2016 - 02/2005
4	Proteins (Proteins, Gene)FDA Link 10/2021 - 05/2011
4	Cadherins (E-Cadherin)IBA 11/2011 - 03/2006
3	monoclonal antibody D2-40IBA 01/2010 - 09/2007
3	CEACAM1 ProteinIBA 08/2009 - 07/2005
2	Tumor Biomarkers (Tumor Markers)IBA 01/2018 - 04/2009
2	Irinotecan (Camptosar)FDA LinkGeneric 10/2015 - 01/2008
2	Leucovorin (Folinic Acid)FDA Link 10/2015 - 10/2009
2	Immunoglobulins (Immunoglobulin)IBA 12/2012 - 07/2007
2	Gemcitabine FDA Link 09/2011 - 01/2008
2	VimentinIBA 03/2011 - 06/2010
2	Capsules (Microcapsules)IBA 05/2010 - 03/2006
2	Cyclin-Dependent Kinase Inhibitor p16IBA 01/2009 - 10/2004
1	LigandsIBA 02/2012
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 09/2011
1	Biomarkers (Surrogate Marker)IBA 08/2011
1	quinone (benzoquinone)IBA 04/2011
1	NAD (NADH)IBA 04/2011
1	SynaptophysinIBA 03/2011
1	Chromogranin AIBA 03/2011
1	EWS-FLI fusion proteinIBA 03/2011
1	lentil lectinIBA 07/2010
1	alpha-Fetoproteins (alpha-Fetoprotein)IBA 07/2010
1	Cisplatin (Platino)FDA LinkGeneric 04/2010
1	Multidrug Resistance-Associated Protein 2IBA 04/2010
1	Transcription Factor MTF-1IBA 01/2010
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2010
1	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2009
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2009
1	Erythropoietin FDA Link 04/2009
1	Messenger RNA (mRNA)IBA 04/2009
1	RNA (Ribonucleic Acid)IBA 04/2009
1	Cell Adhesion MoleculesIBA 12/2008
1	beta CateninIBA 12/2008
1	OsteopontinIBA 12/2008
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2008
1	arseniteIBA 06/2006
1	Hematoxylin (Haematoxylon)IBA 06/2006
1	Eosine Yellowish-(YS) (Eosin)IBA 06/2006
1	CarcinogensIBA 06/2006
1	arsenic acid (arsenate)IBA 06/2006
1	MethyltransferasesIBA 03/2006
1	Arsenic Trioxide (Trisenox)FDA Link 03/2006
1	DNA (Deoxyribonucleic Acid)IBA 03/2006
1	alpha-fluoro-beta-alanine (FBAL)IBA 12/2005

Therapy/Procedure

16	Drug Therapy (Chemotherapy) 01/2018 - 01/2005
16	Hepatectomy 11/2012 - 02/2002
7	Lymph Node Excision (Lymph Node Dissection) 07/2012 - 06/2006
5	Cholecystectomy 09/2012 - 05/2003
4	Pancreaticoduodenectomy 09/2011 - 06/2006
3	Neoadjuvant Therapy 01/2012 - 04/2010
2	Aftercare (After-Treatment) 02/2013 - 08/2009
2	Radiotherapy 02/2013 - 03/2011
2	Proctectomy 01/2009 - 02/2005
2	Metastasectomy 07/2003 - 02/2002
1	Combined Modality Therapy 03/2011
1	Gastrectomy 03/2011
1	Operative Surgical Procedures 08/2010
1	Folfox protocol 10/2009
1	Therapeutics 02/2007
1	Herniorrhaphy 03/2006